f In vivo induction of apoptosis by influenza virus
- Authors: Isamu Mori, Takayuki Komatsu, Kenji Takeuchi, Kazuya Nakakuki, Masakatsu Sudo, Yoshinobu Kimura*
*Author for correspondence. Fax +81 776 61 8104.
- J. Gen. Virol., November 1995 76: 2869-2873, doi: 10.1099/0022-1317-76-11-2869
- Subject: Animal
- Published Online:
Intranasal exposure of mice to influenza virus led to cell death in bronchial/bronchiolar epithelial cells, alveolar cells and lymphoid cells. These cells displayed fragmentation of nuclei and chromatin condensation. Nick end-labelling of DNA in situ confirmed that such apoptotic cells had fragmented DNA. These results suggest that the influenza virus induces apoptosis in vivo.
Author for correspondence. Fax +81 776 61 8104.
© Society for General Microbiology 1995 | Published by the Society for General Microbiology
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