f The Role of Liver in the Catabolism of Human α- and β-Interferon
- Authors: V. Bocci, A. Pacini, L. Bandinelli, G. P. Pessina, M. Muscettola, L. Paulesu
- J. Gen. Virol., June 1982 60: 397-400, doi: 10.1099/0022-1317-60-2-397
- Subject: Animal
- Published Online:
The susceptibility of human leukocyte (α), fibroblast (β) and recombinant α-2-interferons to clearance by the isolated and perfused rabbit liver has been evaluated. Human leukocyte and recombinant α-2-interferons were stable and their initial levels were maintained in the perfusate even if they had been treated with neuraminidase, thus suggesting that α-interferons have no exposed sugars recognizable by hepatic binding proteins. On the other hand, native, and particularly desialylated human β-interferon, underwent marked hepatic uptake confirming the importance of the liver as a catabolic site for glycosylated interferons.
© Society for General Microbiology 1982 | Published by the Society for General Microbiology
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