f Monoclonal Antibodies to Sindbis Virus Glycoprotein E1 can Neutralize, Enhance Infectivity, and Independently Inhibit Haemagglutination or Haemolysis
- Authors: A. C. Chanas, E. A. Gould, J. C. S. Clegg, M. G. R. Varma
- J. Gen. Virol., January 1982 58: 37-46, doi: 10.1099/0022-1317-58-1-37
- Subject: Animal
- Published Online:
Two monoclonal antibodies raised against Sindbis virus were shown to be specific for the envelope glycoprotein E1 by radioimmunoprecipitation (RIP). They had a number of contrasting biological properties. One of them was capable of neutralizing virus infectivity and inhibiting haemagglutination, while the other had no significant neutralizing or haemagglutination-inhibiting capability, but did inhibit virus-mediated haemolysis. Both monoclonal antibodies could enhance virus infectivity of Fc receptor-bearing macrophage-like cells when present at suitable dilutions.
© Society for General Microbiology 1982 | Published by the Society for General Microbiology
Full text loading...
Author and Article Information
Figure data loading....