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The1 Wistar Institute of Anatomy and Biology, 3601 Spruce Street, Philadelphia, Pennsylvania 19104-4268, U.S.A.
and2 Heinrich Pette Institut, Hamburg, Germany
The outcome of herpes simplex virus type 1 (HSV-1) infection depends upon the interplay of both host and viral factors. During lytic infection, HSV-1 causes a loss of immunofluorescent staining of discrete nuclear domains (ND10). This elimination of the host's ND10 staining occurs under conditions that allow only HSV-1 immediate early viral gene expression. Western blot analysis indicates that the loss of ND10 staining is due to ND10 redistribution, rather than protein degradation or turnover. When deletion mutants of all of the HSV-1 immediate early genes were tested, only infection with an immediate early gene 1 product (ICP0) deletion mutant, dl1403, was unable to eliminate ND10 antigen staining. Also, ICP0 transiently colocalized with ND10 antigens, after which ND10 antigens became undetectable. At late times during infection with dl1403, the host ND10 antigens were retained in virus-induced structures which were never observed during wild-type HSV-1 infection. These results suggested that ICP0 may be directly involved in the modification of the host nuclear domain. Infection with an adenovirus recombinant that expressed ICP0 demonstrated that in the absence of other HSV-1 proteins ICP0 was sufficient for the change in nuclear distribution of host antigens located at ND10. We postulate that the trans-activation function of ICP0 during viral replication may be mediated by replacing, modifying or reorganizing nuclear host factors.
Received 5 May 1993;
accepted 3 August 1993.
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D. J. Davido, D. A. Leib, and P. A. Schaffer The Cyclin-Dependent Kinase Inhibitor Roscovitine Inhibits the Transactivating Activity and Alters the Posttranslational Modification of Herpes Simplex Virus Type 1 ICP0 J. Virol., February 1, 2002; 76(3): 1077 - 1088. [Abstract] [Full Text] [PDF]
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R. Hagglund, C. Van Sant, P. Lopez, and B. Roizman Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes PNAS, January 22, 2002; 99(2): 631 - 636. [Abstract] [Full Text] [PDF]
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W. E. Hobbs, D. E. Brough, I. Kovesdi, and N. A. DeLuca Efficient Activation of Viral Genomes by Levels of Herpes Simplex Virus ICP0 Insufficient To Affect Cellular Gene Expression or Cell Survival J. Virol., April 1, 2001; 75(7): 3391 - 3403. [Abstract] [Full Text]
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J. Burkham, D. M. Coen, C. B. C. Hwang, and S. K. Weller Interactions of Herpes Simplex Virus Type 1 with ND10 and Recruitment of PML to Replication Compartments J. Virol., March 1, 2001; 75(5): 2353 - 2367. [Abstract] [Full Text]
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C. Van Sant, P. Lopez, S. J. Advani, and B. Roizman Role of Cyclin D3 in the Biology of Herpes Simplex Virus 1 ICP0 J. Virol., February 15, 2001; 75(4): 1888 - 1898. [Abstract] [Full Text]
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J. Parkinson and R. D. Everett Alphaherpesvirus Proteins Related to Herpes Simplex Virus Type 1 ICP0 Affect Cellular Structures and Proteins J. Virol., November 1, 2000; 74(21): 10006 - 10017. [Abstract] [Full Text]
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E. E. McNamee, T. J Taylor, and D. M. Knipe A Dominant-Negative Herpesvirus Protein Inhibits Intranuclear Targeting of Viral Proteins: Effects on DNA Replication and Late Gene Expression J. Virol., November 1, 2000; 74(21): 10122 - 10131. [Abstract] [Full Text]
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X.-p. Chen, J. Li, M. Mata, J. Goss, D. Wolfe, J. C. Glorioso, and D. J. Fink Herpes Simplex Virus Type 1 ICP0 Protein Does Not Accumulate in the Nucleus of Primary Neurons in Culture J. Virol., November 1, 2000; 74(21): 10132 - 10141. [Abstract] [Full Text]
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Q. Tang, P. Bell, P. Tegtmeyer, and G. G. Maul Replication but Not Transcription of Simian Virus 40 DNA Is Dependent on Nuclear Domain 10 J. Virol., October 15, 2000; 74(20): 9694 - 9700. [Abstract] [Full Text]
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S. L. Boulware and P. C. Weber Cross-reactivity of the anti-PML antibody PG-M3 with the herpes simplex virus type 1 immediate early protein ICP4 J. Gen. Virol., July 1, 2000; 81(7): 1773 - 1777. [Abstract] [Full Text]
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W. E. Hobbs II and N. A. DeLuca Perturbation of Cell Cycle Progression and Cellular Gene Expression as a Function of Herpes Simplex Virus ICP0 J. Virol., October 1, 1999; 73(10): 8245 - 8255. [Abstract] [Full Text] [PDF]
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F. D. Goodrum and D. A. Ornelles Roles for the E4 orf6, orf3, and E1B 55-Kilodalton Proteins in Cell Cycle-Independent Adenovirus Replication J. Virol., September 1, 1999; 73(9): 7474 - 7488. [Abstract] [Full Text]
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C. Van Sant, Y. Kawaguchi, and B. Roizman A single amino acid substitution in the cyclin D binding domain of the infected cell protein no. 0 abrogates the neuroinvasiveness of herpes simplex virus without affecting its ability to replicate PNAS, July 6, 1999; 96(14): 8184 - 8189. [Abstract] [Full Text] [PDF]
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S. Müller and A. Dejean Viral Immediate-Early Proteins Abrogate the Modification by SUMO-1 of PML and Sp100 Proteins, Correlating with Nuclear Body Disruption J. Virol., June 1, 1999; 73(6): 5137 - 5143. [Abstract] [Full Text]
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T. Sternsdorf, K. Jensen, B. Reich, and H. Will The Nuclear Dot Protein Sp100, Characterization of Domains Necessary for Dimerization, Subcellular Localization, and Modification by Small Ubiquitin-like Modifiers J. Biol. Chem., April 30, 1999; 274(18): 12555 - 12566. [Abstract] [Full Text] [PDF]
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 D. A. Leib, T. E. Harrison, K. M. Laslo, M. A. Machalek, N. J. Moorman, and H. W. Virgin Interferons Regulate the Phenotype of Wild-type and Mutant Herpes Simplex Viruses In Vivo J. Exp. Med., February 15, 1999; 189(4): 663 - 672. [Abstract] [Full Text] [PDF]
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C. S. Swindle, N. Zou, B. A. Van Tine, G. M. Shaw, J. A. Engler, and L. T. Chow Human Papillomavirus DNA Replication Compartments in a Transient DNA Replication System J. Virol., February 1, 1999; 73(2): 1001 - 1009. [Abstract] [Full Text]
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R. D. Everett, M. Meredith, and A. Orr The Ability of Herpes Simplex Virus Type 1 Immediate-Early Protein Vmw110 To Bind to a Ubiquitin-Specific Protease Contributes to Its Roles in the Activation of Gene Expression and Stimulation of Virus Replication J. Virol., January 1, 1999; 73(1): 417 - 426. [Abstract] [Full Text] [PDF]
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J. Parkinson, S. P. Lees-Miller, and R. D. Everett Herpes Simplex Virus Type 1 Immediate-Early Protein Vmw110 Induces the Proteasome-Dependent Degradation of the Catalytic Subunit of DNA-Dependent Protein Kinase J. Virol., January 1, 1999; 73(1): 650 - 657. [Abstract] [Full Text] [PDF]
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J. Burkham, D. M. Coen, and S. K. Weller ND10 Protein PML Is Recruited to Herpes Simplex Virus Type 1 Prereplicative Sites and Replication Compartments in the Presence of Viral DNA Polymerase J. Virol., December 1, 1998; 72(12): 10100 - 10107. [Abstract] [Full Text] [PDF]
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M. D. Petroski and E. K. Wagner Purification and Characterization of a Cellular Protein That Binds to the Downstream Activation Sequence of the Strict Late UL38 Promoter of Herpes Simplex Virus Type 1 J. Virol., October 1, 1998; 72(10): 8181 - 8190. [Abstract] [Full Text] [PDF]
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R. D. Everett, P. Freemont, H. Saitoh, M. Dasso, A. Orr, M. Kathoria, and J. Parkinson The Disruption of ND10 during Herpes Simplex Virus Infection Correlates with the Vmw110- and Proteasome-Dependent Loss of Several PML Isoforms J. Virol., August 1, 1998; 72(8): 6581 - 6591. [Abstract] [Full Text] [PDF]
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J.-H. Ahn, E. J. Brignole III, and G. S. Hayward Disruption of PML Subnuclear Domains by the Acidic IE1 Protein of Human Cytomegalovirus Is Mediated through Interaction with PML and May Modulate a RING Finger-Dependent Cryptic Transactivator Function of PML Mol. Cell. Biol., August 1, 1998; 18(8): 4899 - 4913. [Abstract] [Full Text]
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R. Jordan, J. Pepe, and P. A. Schaffer Characterization of a Nerve Growth Factor-Inducible Cellular Activity That Enhances Herpes Simplex Virus Type 1 Gene Expression and Replication of an ICP0 Null Mutant in Cells of Neural Lineage J. Virol., July 1, 1998; 72(7): 5373 - 5382. [Abstract] [Full Text] [PDF]
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 A. I. Lamond and W. C. Earnshaw Structure and Function in the Nucleus Science, April 24, 1998; 280(5363): 547 - 553. [Abstract] [Full Text]
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L. A. Samaniego, L. Neiderhiser, and N. A. DeLuca Persistence and Expression of the Herpes Simplex Virus Genome in the Absence of Immediate-Early Proteins J. Virol., April 1, 1998; 72(4): 3307 - 3320. [Abstract] [Full Text] [PDF]
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K. L. B. Borden, E. J. Campbell Dwyer, and M. S. Salvato An Arenavirus RING (Zinc-Binding) Protein Binds the Oncoprotein Promyelocyte Leukemia Protein (PML) and Relocates PML Nuclear Bodies to the Cytoplasm J. Virol., January 1, 1998; 72(1): 758 - 766. [Abstract] [Full Text] [PDF]
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T. Sternsdorf, K. Jensen, and H. Will Evidence for Covalent Modification of the Nuclear Dot-associated Proteins PML and Sp100 by PIC1/SUMO-1 J. Cell Biol., December 29, 1997; 139(7): 1621 - 1634. [Abstract] [Full Text] [PDF]
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A. M. Ishov, R. M. Stenberg, and G. G. Maul Human Cytomegalovirus Immediate Early Interaction with Host Nuclear Structures: Definition of an Immediate Transcript Environment J. Cell Biol., July 14, 1997; 138(1): 5 - 16. [Abstract] [Full Text] [PDF]
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D. B. Bloch, S. M. de la Monte, P. Guigaouri, A. Filippov, and K. D. Bloch Identification and Characterization of a Leukocyte-specific Component of the Nuclear Body J. Biol. Chem., November 15, 1996; 271(46): 29198 - 29204. [Abstract] [Full Text] [PDF]
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T. Grotzinger, K. Jensen, and H. Will The Interferon (IFN)-stimulated Gene Sp100 Promoter Contains an IFN-gamma Activation Site and an Imperfect IFN-stimulated Response Element Which Mediate Type I IFN Inducibility J. Biol. Chem., October 11, 1996; 271(41): 25253 - 25260. [Abstract] [Full Text] [PDF]
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P. L. Sheridan, M. Schorpp, M. L. Voz, and K. A. Jones Cloning of an SNF2/SWI2-related Protein That Binds Specifically to the SPH Motifs of the SV40 Enhancer and to the HIV-1 Promoter J. Biol. Chem., March 3, 1995; 270(9): 4575 - 4587. [Abstract] [Full Text] [PDF]
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P. Lomonte, K. F. Sullivan, and R. D. Everett Degradation of Nucleosome-associated Centromeric Histone H3-like Protein CENP-A Induced by Herpes Simplex Virus Type 1 Protein ICP0 J. Biol. Chem., February 16, 2001; 276(8): 5829 - 5835. [Abstract] [Full Text] [PDF]
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Y. Kawaguchi, M. Tanaka, A. Yokoymama, G. Matsuda, K. Kato, H. Kagawa, K. Hirai, and B. Roizman Herpes simplex virus 1 alpha regulatory protein ICP0 functionally interacts with cellular transcription factor BMAL1 PNAS, February 13, 2001; 98(4): 1877 - 1882. [Abstract] [Full Text] [PDF]
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