| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Medicine, University of Cambridge Clinical School, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, U.K.
We have used the nested polymerase chain reaction (PCR) combined with fluorescence-activated cell sorting to define sites of latency of human cytomegalovirus (HCMV) in the peripheral blood of healthy subjects. Peripheral blood mononuclear (PBM) cells were separated into T cell or non-T cell populations and monocytes, and were then analysed by PCR for the presence of HCMV DNA. In five of six seropositive subjects, HCMV was found predominantly in the non-T cell population. Further analysis suggested that the virus was present in adherent cells and CD14+ cells. In three of nine seronegative subjects we could demonstrate HCMV DNA, which we do not believe was due to contamination, reproducibly by PCR. In one of these seronegative subjects, HCMV DNA was present predominantly in the non-T cell fraction of PBM cells. No HCMV DNA was detectable in the remaining six seronegative subjects. We conclude that, within the PBM cells of normal asymptomatic seropositive and some seronegative subjects, HCMV is present predominantly in the monocyte fraction. In addition, the detection of HCMV sequences in seronegative subjects may indicate that infection with HCMV is more widespread than conventional seroepidemiology suggests.
Present address: Department of Medicine, University of Wales, College of Medicine, Heath Park, Cardiff CF4 4XN, U.K.
Received 30 January 1991;
accepted 3 June 1991.
This article has been cited by other articles:
|
|
 |
|
  A. K. L. Cheung, D. J. Gottlieb, B. Plachter, S. Pepperl-Klindworth, S. Avdic, A. L. Cunningham, A. Abendroth, and B. Slobedman The role of the human cytomegalovirus UL111A gene in down-regulating CD4+ T-cell recognition of latently infected cells: implications for virus elimination during latency Blood, November 5, 2009; 114(19): 4128 - 4137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Petrucelli, M. Rak, L. Grainger, and F. Goodrum Characterization of a Novel Golgi Apparatus-Localized Latency Determinant Encoded by Human Cytomegalovirus J. Virol., June 1, 2009; 83(11): 5615 - 5629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. T. Garnett, G. Talekar, J. A. Mahr, W. Huang, Y. Zhang, D. A. Ornelles, and L. R. Gooding Latent Species C Adenoviruses in Human Tonsil Tissues J. Virol., March 15, 2009; 83(6): 2417 - 2428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kuttruff, S. Koch, A. Kelp, G. Pawelec, H.-G. Rammensee, and A. Steinle NKp80 defines and stimulates a reactive subset of CD8 T cells Blood, January 8, 2009; 113(2): 358 - 369. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Crough and R. Khanna Immunobiology of Human Cytomegalovirus: from Bench to Bedside Clin. Microbiol. Rev., January 1, 2009; 22(1): 76 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Frascaroli, S. Varani, N. Blankenhorn, R. Pretsch, M. Bacher, L. Leng, R. Bucala, M. P. Landini, and T. Mertens Human Cytomegalovirus Paralyzes Macrophage Motility through Down-Regulation of Chemokine Receptors, Reorganization of the Cytoskeleton, and Release of Macrophage Migration Inhibitory Factor J. Immunol., January 1, 2009; 182(1): 477 - 488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Chan, E. R. Bivins-Smith, M. S. Smith, P. M. Smith, and A. D. Yurochko Transcriptome Analysis Reveals Human Cytomegalovirus Reprograms Monocyte Differentiation toward an M1 Macrophage J. Immunol., July 1, 2008; 181(1): 698 - 711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Jenkins, W. Garcia, M. J. Godwin, J. V. Spencer, J. L. Stern, A. Abendroth, and B. Slobedman Immunomodulatory Properties of a Viral Homolog of Human Interleukin-10 Expressed by Human Cytomegalovirus during the Latent Phase of Infection J. Virol., April 1, 2008; 82(7): 3736 - 3750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Isomura, M. F. Stinski, A. Kudoh, T. Murata, S. Nakayama, Y. Sato, S. Iwahori, and T. Tsurumi Noncanonical TATA Sequence in the UL44 Late Promoter of Human Cytomegalovirus Is Required for the Accumulation of Late Viral Transcripts J. Virol., February 15, 2008; 82(4): 1638 - 1646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Isomura, M. F. Stinski, A. Kudoh, S. Nakayama, T. Murata, Y. Sato, S. Iwahori, and T. Tsurumi A cis Element between the TATA Box and the Transcription Start Site of the Major Immediate-Early Promoter of Human Cytomegalovirus Determines Efficiency of Viral Replication J. Virol., January 15, 2008; 82(2): 849 - 858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Saffert and R. F. Kalejta Human Cytomegalovirus Gene Expression Is Silenced by Daxx-Mediated Intrinsic Immune Defense in Model Latent Infections Established In Vitro J. Virol., September 1, 2007; 81(17): 9109 - 9120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Goodrum, M. Reeves, J. Sinclair, K. High, and T. Shenk Human cytomegalovirus sequences expressed in latently infected individuals promote a latent infection in vitro Blood, August 1, 2007; 110(3): 937 - 945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Smith, E. R. Bivins-Smith, A. M. Tilley, G. L. Bentz, G. Chan, J. Minard, and A. D. Yurochko Roles of Phosphatidylinositol 3-Kinase and NF-{kappa}B in Human Cytomegalovirus-Mediated Monocyte Diapedesis and Adhesion: Strategy for Viral Persistence J. Virol., July 15, 2007; 81(14): 7683 - 7694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. L. Cheung, A. Abendroth, A. L. Cunningham, and B. Slobedman Viral gene expression during the establishment of human cytomegalovirus latent infection in myeloid progenitor cells Blood, December 1, 2006; 108(12): 3691 - 3699. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Maheshwari, L. E. Smythies, X. Wu, L. Novak, R. Clements, D. Eckhoff, A. J. Lazenby, W. J. Britt, and P. D. Smith Cytomegalovirus blocks intestinal stroma-induced down-regulation of macrophage HIV-1 infection. J. Leukoc. Biol., November 1, 2006; 80(5): 1111 - 1117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Frascaroli, S. Varani, B. Moepps, C. Sinzger, M. P. Landini, and T. Mertens Human cytomegalovirus subverts the functions of monocytes, impairing chemokine-mediated migration and leukocyte recruitment. J. Virol., August 1, 2006; 80(15): 7578 - 7589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sinclair and P. Sissons Latency and reactivation of human cytomegalovirus J. Gen. Virol., July 1, 2006; 87(7): 1763 - 1779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Reeves, P. J. Lehner, J. G. P. Sissons, and J. H. Sinclair An in vitro model for the regulation of human cytomegalovirus latency and reactivation in dendritic cells by chromatin remodelling J. Gen. Virol., November 1, 2005; 86(11): 2949 - 2954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bego, J. Maciejewski, S. Khaiboullina, G. Pari, and S. St. Jeor Characterization of an Antisense Transcript Spanning the UL81-82 Locus of Human Cytomegalovirus J. Virol., September 1, 2005; 79(17): 11022 - 11034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Isomura, M. F. Stinski, A. Kudoh, T. Daikoku, N. Shirata, and T. Tsurumi Two Sp1/Sp3 Binding Sites in the Major Immediate-Early Proximal Enhancer of Human Cytomegalovirus Have a Significant Role in Viral Replication J. Virol., August 1, 2005; 79(15): 9597 - 9607. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Reeves, P. A. MacAry, P. J. Lehner, J. G. P. Sissons, and J. H. Sinclair Latency, chromatin remodeling, and reactivation of human cytomegalovirus in the dendritic cells of healthy carriers PNAS, March 15, 2005; 102(11): 4140 - 4145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Wright, M. Bain, L. Teague, J. Murphy, and J. Sinclair Ets-2 repressor factor recruits histone deacetylase to silence human cytomegalovirus immediate-early gene expression in non-permissive cells J. Gen. Virol., March 1, 2005; 86(3): 535 - 544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Khan, R. Bruton, G. S. Taylor, M. Cobbold, T. R. Jones, A. B. Rickinson, and P. A. H. Moss Identification of Cytomegalovirus-Specific Cytotoxic T Lymphocytes In Vitro Is Greatly Enhanced by the Use of Recombinant Virus Lacking the US2 to US11 Region or Modified Vaccinia Virus Ankara Expressing Individual Viral Genes J. Virol., March 1, 2005; 79(5): 2869 - 2879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gerna, E. Percivalle, D. Lilleri, L. Lozza, C. Fornara, G. Hahn, F. Baldanti, and M. G. Revello Dendritic-cell infection by human cytomegalovirus is restricted to strains carrying functional UL131-128 genes and mediates efficient viral antigen presentation to CD8+ T cells J. Gen. Virol., February 1, 2005; 86(2): 275 - 284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Jaber, G. Chanques, J. Borry, B. Souche, R. Verdier, P.-F. Perrigault, and J.-J. Eledjam Cytomegalovirus Infection in Critically Ill Patients: Associated Factors and Consequences Chest, January 1, 2005; 127(1): 233 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Isomura, T. Tsurumi, and M. F. Stinski Role of the Proximal Enhancer of the Major Immediate-Early Promoter in Human Cytomegalovirus Replication J. Virol., December 1, 2004; 78(23): 12788 - 12799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Kulesza and T. Shenk Human Cytomegalovirus 5-Kilobase Immediate-Early RNA Is a Stable Intron J. Virol., December 1, 2004; 78(23): 13182 - 13189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Reeves, H. Coleman, J. Chadderton, M. Goddard, J. G. P. Sissons, and J. H. Sinclair Vascular endothelial and smooth muscle cells are unlikely to be major sites of latency of human cytomegalovirus in vivo J. Gen. Virol., November 1, 2004; 85(11): 3337 - 3341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gredmark, W. B. Britt, X. Xie, L. Lindbom, and C. Soderberg-Naucler Human Cytomegalovirus Induces Inhibition of Macrophage Differentiation by Binding to Human Aminopeptidase N/CD13 J. Immunol., October 15, 2004; 173(8): 4897 - 4907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gredmark, T. Tilburgs, and C. Soderberg-Naucler Human Cytomegalovirus Inhibits Cytokine-Induced Macrophage Differentiation J. Virol., October 1, 2004; 78(19): 10378 - 10389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Goodrum, C. T. Jordan, S. S. Terhune, K. High, and T. Shenk Differential outcomes of human cytomegalovirus infection in primitive hematopoietic cell subpopulations Blood, August 1, 2004; 104(3): 687 - 695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Smith, G. L. Bentz, P. M. Smith, E. R. Bivins, and A. D. Yurochko HCMV activates PI(3)K in monocytes and promotes monocyte motility and transendothelial migration in a PI(3)K-dependent manner J. Leukoc. Biol., July 1, 2004; 76(1): 65 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Smith, G. L. Bentz, J. S. Alexander, and A. D. Yurochko Human Cytomegalovirus Induces Monocyte Differentiation and Migration as a Strategy for Dissemination and Persistence J. Virol., May 1, 2004; 78(9): 4444 - 4453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Slobedman, J. L. Stern, A. L. Cunningham, A. Abendroth, D. A. Abate, and E. S. Mocarski Impact of Human Cytomegalovirus Latent Infection on Myeloid Progenitor Cell Gene Expression J. Virol., April 15, 2004; 78(8): 4054 - 4062. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. I. M. C. Guedes, J. M. Risdahl, B. Wiseman, and T. W. Molitor Reactivation of Porcine Cytomegalovirus through Allogeneic Stimulation J. Clin. Microbiol., April 1, 2004; 42(4): 1756 - 1758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Jenkins, A. Abendroth, and B. Slobedman A Novel Viral Transcript with Homology to Human Interleukin-10 Is Expressed during Latent Human Cytomegalovirus Infection J. Virol., February 1, 2004; 78(3): 1440 - 1447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L. Nerheim, J. L. Meier, M. A. Vasef, W.-G. Li, L. Hu, J. B. Rice, D. Gavrila, W. E. Richenbacher, and N. L. Weintraub Enhanced Cytomegalovirus Infection in Atherosclerotic Human Blood Vessels Am. J. Pathol., February 1, 2004; 164(2): 589 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Visconti, J. Pennington, S. F. Garner, J.-P. Allain, and L. M. Williamson Assessment of removal of human cytomegalovirus from blood components by leukocyte depletion filters using real-time quantitative PCR Blood, February 1, 2004; 103(3): 1137 - 1139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kondo, Y. Akatsuka, K. Kuzushima, K. Tsujimura, S. Asakura, K. Tajima, Y. Kagami, Y. Kodera, M. Tanimoto, Y. Morishima, et al. Identification of novel CTL epitopes of CMV-pp65 presented by a variety of HLA alleles Blood, January 15, 2004; 103(2): 630 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gredmark and C. Soderberg-Naucler Human Cytomegalovirus Inhibits Differentiation of Monocytes into Dendritic Cells with the Consequence of Depressed Immunological Functions J. Virol., October 15, 2003; 77(20): 10943 - 10956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kondo, H. Nozaki, K. Shimada, and K. Yamanishi Detection of a Gene Cluster That Is Dispensable for Human Herpesvirus 6 Replication and Latency J. Virol., October 1, 2003; 77(19): 10719 - 10724. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. C. Geddes, C. C. Church, T. Collidge, E. A. B. McCruden, G. Gillespie, E. Matthews, A. Hainmueller, and J. D. Briggs Management of cytomegalovirus infection by weekly surveillance after renal transplant: analysis of cost, rejection and renal function Nephrol. Dial. Transplant., September 1, 2003; 18(9): 1891 - 1898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Isomura and M. F. Stinski The Human Cytomegalovirus Major Immediate-Early Enhancer Determines the Efficiency of Immediate-Early Gene Transcription and Viral Replication in Permissive Cells at Low Multiplicity of Infection J. Virol., March 15, 2003; 77(6): 3602 - 3614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kondo, J. Sashihara, K. Shimada, M. Takemoto, K. Amo, H. Miyagawa, and K. Yamanishi Recognition of a Novel Stage of Betaherpesvirus Latency in Human Herpesvirus 6 J. Virol., February 1, 2003; 77(3): 2258 - 2264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bain, M. Mendelson, and J. Sinclair Ets-2 Repressor Factor (ERF) mediates repression of the human cytomegalovirus major immediate-early promoter in undifferentiated non-permissive cells J. Gen. Virol., January 1, 2003; 84(1): 41 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. D. Goodrum, C. T. Jordan, K. High, and T. Shenk Human cytomegalovirus gene expression during infection of primary hematopoietic progenitor cells: A model for latency PNAS, December 10, 2002; 99(25): 16255 - 16260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Stanton, J. D. Fox, R. Caswell, E. Sherratt, and G. W. G. Wilkinson Analysis of the human herpesvirus-6 immediate-early 1 protein J. Gen. Virol., November 1, 2002; 83(11): 2811 - 2820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-C. Ku, J. A. Padilla, C. Grose, E. C. Butcher, and A. M. Arvin Tropism of Varicella-Zoster Virus for Human Tonsillar CD4+ T Lymphocytes That Express Activation, Memory, and Skin Homing Markers J. Virol., October 11, 2002; 76(22): 11425 - 11433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Revello and G. Gerna Diagnosis and Management of Human Cytomegalovirus Infection in the Mother, Fetus, and Newborn Infant Clin. Microbiol. Rev., October 1, 2002; 15(4): 680 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Slobedman, E. S. Mocarski, A. M. Arvin, E. D. Mellins, and A. Abendroth Latent cytomegalovirus down-regulates major histocompatibility complex class II expression on myeloid progenitors Blood, September 26, 2002; 100(8): 2867 - 2873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Kercher and B. M. Mitchell Persisting Murine Cytomegalovirus Can Reactivate and Has Unique Transcriptional Activity in Ocular Tissue J. Virol., August 12, 2002; 76(18): 9165 - 9175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gerna, E. Percivalle, A. Sarasini, F. Baldanti, and M. G. Revello The attenuated Towne strain of human cytomegalovirus may revert to both endothelial cell tropism and leuko- (neutrophil- and monocyte-) tropism in vitro J. Gen. Virol., August 1, 2002; 83(8): 1993 - 2000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Soderberg-Naucler, D. N. Streblow, K. N. Fish, J. Allan-Yorke, P. P. Smith, and J. A. Nelson Reactivation of Latent Human Cytomegalovirus in CD14+ Monocytes Is Differentiation Dependent J. Virol., August 15, 2001; 75(16): 7543 - 7554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Bernier, T. Tschernig, R. Pabst, O. Macke, C. Steinmueller, and A. Emmendorffer Effects of macrophage-CSF on pulmonary-macrophage repopulation after bone marrow transplantation J. Leukoc. Biol., July 1, 2001; 70(1): 39 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Dumont, J. Luka, T. VandenBroeke, P. Whitley, D. R. Ambruso, and M. D. Elfath The effect of leukocyte-reduction method on the amount of human cytomegalovirus in blood products: a comparison of apheresis and filtration methods Blood, June 1, 2001; 97(11): 3640 - 3647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hummel, Z. Zhang, S. Yan, I. DePlaen, P. Golia, T. Varghese, G. Thomas, and M. I. Abecassis Allogeneic Transplantation Induces Expression of Cytomegalovirus Immediate-Early Genes In Vivo: a Model for Reactivation from Latency J. Virol., May 15, 2001; 75(10): 4814 - 4822. [Abstract] [Full Text]
|
|
|
|
|
|
N. K. A. Grzimek, D. Dreis, S. Schmalz, and M. J. Reddehase Random, Asynchronous, and Asymmetric Transcriptional Activity of Enhancer-Flanking Major Immediate-Early Genes ie1/3 and ie2 during Murine Cytomegalovirus Latency in the Lungs J. Virol., March 15, 2001; 75(6): 2692 - 2705. [Abstract] [Full Text]
|
|
|
|
|
|
J. L. Meier Reactivation of the Human Cytomegalovirus Major Immediate-Early Regulatory Region and Viral Replication in Embryonal NTera2 Cells: Role of Trichostatin A, Retinoic Acid, and Deletion of the 21-Base-Pair Repeats and Modulator J. Virol., February 15, 2001; 75(4): 1581 - 1593. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Kaul, J. Uphoff, J. Wiedeman, S. Yadlapalli, and W. M. Wenman Detection of Chlamydia pneumoniae DNA in CD3+ Lymphocytes From Healthy Blood Donors and Patients With Coronary Artery Disease Circulation, November 7, 2000; 102(19): 2341 - 2346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. White, B. Slobedman, and E. S. Mocarski Human Cytomegalovirus Latency-Associated Protein pORF94 Is Dispensable for Productive and Latent Infection J. Virol., October 1, 2000; 74(19): 9333 - 9337. [Abstract] [Full Text]
|
|
|
|
|
|
H. Hengel, U. Reusch, G. Geginat, R. Holtappels, T. Ruppert, E. Hellebrand, and U. H. Koszinowski Macrophages Escape Inhibition of Major Histocompatibility Complex Class I-Dependent Antigen Presentation by Cytomegalovirus J. Virol., September 1, 2000; 74(17): 7861 - 7868. [Abstract] [Full Text]
|
|
|
|
|
|
G. M. A. Gillespie, M. R. Wills, V. Appay, C. O'Callaghan, M. Murphy, N. Smith, P. Sissons, S. Rowland-Jones, J. I. Bell, and P. A. H. Moss Functional Heterogeneity and High Frequencies of Cytomegalovirus-Specific CD8+ T Lymphocytes in Healthy Seropositive Donors J. Virol., September 1, 2000; 74(17): 8140 - 8150. [Abstract] [Full Text]
|
|
|
|
|
|
G. Gerna, E. Percivalle, F. Baldanti, S. Sozzani, P. Lanzarini, E. Genini, D. Lilleri, and M. G. Revello Human Cytomegalovirus Replicates Abortively in Polymorphonuclear Leukocytes after Transfer from Infected Endothelial Cells via Transient Microfusion Events J. Virol., June 15, 2000; 74(12): 5629 - 5638. [Abstract] [Full Text]
|
|
|
|
|
|
M. Onno, C. Pangault, G. Le Friec, V. Guilloux, P. Andre, and R. Fauchet Modulation of HLA-G Antigens Expression by Human Cytomegalovirus: Specific Induction in Activated Macrophages Harboring Human Cytomegalovirus Infection J. Immunol., June 15, 2000; 164(12): 6426 - 6434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Retière, V. Prod'homme, B.-M. Imbert-Marcille, M. Bonneville, H. Vié, and M.-M. Hallet Generation of Cytomegalovirus-Specific Human T-Lymphocyte Clones by Using Autologous B-Lymphoblastoid Cells with Stable Expression of pp65 or IE1 Proteins: a Tool To Study the Fine Specificity of the Antiviral Response J. Virol., May 1, 2000; 74(9): 3948 - 3952. [Abstract] [Full Text]
|
|
|
|
|
|
J. L. Meier and J. A. Pruessner The Human Cytomegalovirus Major Immediate-Early Distal Enhancer Region Is Required for Efficient Viral Replication and Immediate-Early Gene Expression J. Virol., February 15, 2000; 74(4): 1602 - 1613. [Abstract] [Full Text]
|
|
|
|
|
|
A. Esclatine, M. Lemullois, A. L. Servin, A.-M. Quero, and M. Geniteau-Legendre Human Cytomegalovirus Infects Caco-2 Intestinal Epithelial Cells Basolaterally Regardless of the Differentiation State J. Virol., January 1, 2000; 74(1): 513 - 517. [Abstract] [Full Text]
|
|
|
|
|
|
C. A. Lundquist, J. L. Meier, and M. F. Stinski A Strong Negative Transcriptional Regulatory Region between the Human Cytomegalovirus UL127 Gene and the Major Immediate-Early Enhancer J. Virol., November 1, 1999; 73(11): 9039 - 9052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Lockridge, G. Sequar, S. S. Zhou, Y. Yue, C. P. Mandell, and P. A. Barry Pathogenesis of Experimental Rhesus Cytomegalovirus Infection J. Virol., November 1, 1999; 73(11): 9576 - 9583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Bodaghi, M. E. P. Slobbe-vanDrunen, A. Topilko, E. Perret, R. C. R. M. Vossen, M. C. E. van Dam-Mieras, D. Zipeto, J.-L. Virelizier, P. LeHoang, C. A. Bruggeman, et al. Entry of Human Cytomegalovirus into Retinal Pigment Epithelial and Endothelial Cells by Endocytosis Invest. Ophthalmol. Vis. Sci., October 1, 1999; 40(11): 2598 - 2607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. T. Penfold, D. J. Dairaghi, G. M. Duke, N. Saederup, E. S. Mocarski, G. W. Kemble, and T. J. Schall Cytomegalovirus encodes a potent alpha chemokine PNAS, August 17, 1999; 96(17): 9839 - 9844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Slobedman and E. S. Mocarski Quantitative Analysis of Latent Human Cytomegalovirus J. Virol., June 1, 1999; 73(6): 4806 - 4812. [Abstract] [Full Text]
|
|
|
|
|
|
S. Redpath, A. Angulo, N. R. J. Gascoigne, and P. Ghazal Murine Cytomegalovirus Infection Down-Regulates MHC Class II Expression on Macrophages by Induction of IL-10 J. Immunol., June 1, 1999; 162(11): 6701 - 6707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Boyle, R. L. Pietropaolo, and T. Compton Engagement of the Cellular Receptor for Glycoprotein B of Human Cytomegalovirus Activates the Interferon-Responsive Pathway Mol. Cell. Biol., May 1, 1999; 19(5): 3607 - 3613. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Zipeto, B Bodaghi, L Laurent, J. Virelizier, and S Michelson Kinetics of transcription of human cytomegalovirus chemokine receptor US28 in different cell types J. Gen. Virol., March 1, 1999; 80(3): 543 - 547. [Abstract]
|
|
|
|
|
|
S. K. Kurz, M. Rapp, H.-P. Steffens, N. K. A. Grzimek, S. Schmalz, and M. J. Reddehase Focal Transcriptional Activity of Murine Cytomegalovirus during Latency in the Lungs J. Virol., January 1, 1999; 73(1): 482 - 494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Bolovan-Fritts, E. S. Mocarski, and J. A. Wiedeman Peripheral Blood CD14+ Cells From Healthy Subjects Carry a Circular Conformation of Latent Cytomegalovirus Genome Blood, January 1, 1999; 93(1): 394 - 398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Prösch, E. Schielke, A. Reip, H. Meisel, H.-D. Volk, K. M. Einhäupl, and D. H. Krüger Human Cytomegalovirus (HCMV) Encephalitis in an Immunocompetent Young Person and Diagnostic Reliability of HCMV DNA PCR Using Cerebrospinal Fluid of Nonimmunosuppressed Patients J. Clin. Microbiol., December 1, 1998; 36(12): 3636 - 3640. [Abstract] [Full Text]
|
|
|
|
|
|
P. E. Lashmit, M. F. Stinski, E. A. Murphy, and G. C. Bullock A cis Repression Sequence Adjacent to the Transcription Start Site of the Human Cytomegalovirus US3 Gene Is Required To Down Regulate Gene Expression at Early and Late Times after Infection J. Virol., December 1, 1998; 72(12): 9575 - 9584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Rodems and D. H. Spector Extracellular Signal-Regulated Kinase Activity Is Sustained Early during Human Cytomegalovirus Infection J. Virol., November 1, 1998; 72(11): 9173 - 9180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Vieira, T. J. Schall, L. Corey, and A. P. Geballe Functional Analysis of the Human Cytomegalovirus US28 Gene by Insertion Mutagenesis with the Green Fluorescent Protein Gene J. Virol., October 1, 1998; 72(10): 8158 - 8165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. N. Fish, C. Soderberg-Naucler, and J. A. Nelson Steady-State Plasma Membrane Expression of Human Cytomegalovirus gB Is Determined by the Phosphorylation State of Ser900 J. Virol., August 1, 1998; 72(8): 6657 - 6664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Maidji, S. Tugizov, G. Abenes, T. Jones, and L. Pereira A Novel Human Cytomegalovirus Glycoprotein, gpUS9, Which Promotes Cell-to-Cell Spread in Polarized Epithelial Cells, Colocalizes with the Cytoskeletal Proteins E-Cadherin and F-Actin J. Virol., July 1, 1998; 72(7): 5717 - 5727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Schäfer, W. Tenschert, L. Cremaschi, K. Gutensohn, and R. Laufs Utility of Major Leukocyte Subpopulations for Monitoring Secondary Cytomegalovirus Infections in Renal-Allograft Recipients by PCR J. Clin. Microbiol., April 1, 1998; 36(4): 1008 - 1014. [Abstract] [Full Text]
|
|
|
|
|
|
G. Hahn, R. Jores, and E. S. Mocarski Cytomegalovirus remains latent in a common precursor of dendritic and myeloid cells PNAS, March 31, 1998; 95(7): 3937 - 3942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. N. Ho, C.-Y. Lo, I. K. P. Cheng, and T.-M. Chan Rapid Cytomegalovirus pp65 Antigenemia Assay by Direct Erythrocyte Lysis and Immunofluorescence Staining J. Clin. Microbiol., March 1, 1998; 36(3): 638 - 640. [Abstract] [Full Text]
|
|
|
|
|
|
A. J. Koffron, M. Hummel, B. K. Patterson, S. Yan, D. B. Kaufman, J. P. Fryer, F. P. Stuart, and M. I. Abecassis Cellular Localization of Latent Murine Cytomegalovirus J. Virol., January 1, 1998; 72(1): 95 - 103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Zhuravskaya, J.P. Maciejewski, D.M. Netski, E. Bruening, F.R. Mackintosh, and S. St Jeor Spread of Human Cytomegalovirus (HCMV) After Infection of Human Hematopoietic Progenitor Cells: Model of HCMV Latency Blood, September 15, 1997; 90(6): 2482 - 2491. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Guetta, V. Guetta, T. Shibutani, and S. E. Epstein Monocytes Harboring Cytomegalovirus: Interactions With Endothelial Cells, Smooth Muscle Cells, and Oxidized Low-Density Lipoprotein : Possible Mechanisms for Activating Virus Delivered by Monocytes to Sites of Vascular Injury Circ. Res., July 19, 1997; 81(1): 8 - 16. [Abstract] [Full Text]
|
|
|
|
|
|
K. Staak, S. Prosch, J. Stein, C. Priemer, R. Ewert, W.-D. Docke, D. H. Kruger, H. D. Volk, and P. Reinke Pentoxifylline Promotes Replication of Human Cytomegalovirus In Vivo and In Vitro Blood, May 15, 1997; 89(10): 3682 - 3690. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
