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Originally published as JGV in Press, 10.1099/vir.0.011791-0 on July 8, 2009 J Gen Virol 90 (2009), 2788-2797; DOI 10.1099/vir.0.011791-0

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Bovine leukemia virus can be classified into seven genotypes: evidence for the existence of two novel clades

Sabrina M. Rodriguez1, Marcelo D. Golemba2, Rodolfo H. Campos2, Karina Trono1 and Leandro R. Jones3

1 Instituto de Virología, CNIA, INTA-Castelar, Argentina
2 Cátedra de Virología, Facultad de Farmacia y Bioquímica, UBA, Argentina
3 Division of Molecular Biology, Estación de Fotobiología Playa Unión, CC 15, Rawson, Chubut 9103, Argentina

Correspondence
Leandro R. Jones
lrj{at}efpu.org.ar

Previous studies have classified the env sequences of bovine leukemia virus (BLV) provirus from different locations worldwide into between two and four genetic groupings. These different studies gave unique names to the identified groups and no study has yet integrated all the available sequences. Thus, we hypothesized that many of the different groups previously identified actually correspond to a limited group of genotypes that are unevenly distributed worldwide. To examine this hypothesis, we sequenced the env gene from 28 BLV field strains and compared these sequences to 46 env sequences that represent all the genetic groupings already identified. By using phylogenetic analyses, we recovered six clades, or genotypes, that we have called genotypes 1, 2, 3, 4, 5 and 6. Genotypes 1–5 have counterparts among the sequence groupings identified previously. One env sequence did not cluster with any of the others and was highly divergent when compared with the six genotypes identified here. Thus, an extra genotype, which we named 7, may exist. Similarity comparisons were highly congruent with phylogenetic analyses. Furthermore, our analyses confirmed the existence of geographical clusters.

The GenBank/EMBL/DDBJ accession numbers for the sequences identified in this study are FJ808571–FJ808598.

Five supplementary figures and a supplementary table are available with the online version of this paper.






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