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Short Communication |
1 Laboratório Nacional de Investigação Veterinária, Lisboa, Portugal
2 Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal
3 Laboratório de Microbiologia, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
Correspondence
J. Pedro Simas
jpsimas{at}igc.gulbenkian.pt
Experimental transmission of bovine spongiform encephalopathy to sheep has prompted the implementation of a surveillance plan of scrapie in small ruminants by the European Union in all member states. Since its start over 30 000 animals have been tested, and the first seven cases of sheep with detectable PrPres deposition in the central nervous system have been identified in Portugal. Notably, the pattern of PrPres distribution in the brainstem was different from that previously described for scrapie and consistent in all seven animals. Moreover, the profile of the electrophoretic mobility of PrPres after proteinase K treatment was equivalent in all cases analysed but distinct from that observed for scrapie. Notably, four animals had genotypes rarely associated with scrapie, including one animal homozygous for A136R154R171. There were no cases found to exhibit vacuolation, a pattern of PrPres distribution or PrPres electrophoretic mobility corresponding to scrapie. These data reveal a putative atypical scrapie strain in Portugal not linked to specific Prnp genotypes.
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