HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chen, S.-L. Articles by Yang, Y.-F. Search for Related Content PubMed PubMed Citation Articles by Chen, S.-L. Articles by Yang, Y.-F. Agricola Articles by Chen, S.-L. Articles by Yang, Y.-F.

Coincidental expression of E5a and c-jun in human papillomavirus type 6/11-infected condylomata

¹ Department of Microbiology & Immunology, National Defense Medical Center, Taipei
² Department of Obstetrics & Gynecology, Tri-Service General Hospital, Taipei
and³ Department of Obstetrics & Gynecology, The 803 Army General Hospital, Taichung, Taiwan, Republic of China

Previously, we have shown that E5a can induce ex pression of the c-jun gene in human papillomavirus (HPV)-11 E5a transformed NIH 3T3 cells and human epidermal keratinocytes. In this study, we investigated the relationship between expression of the E5a gene and c-jun in pathologically confirmed condylomata specimens using mRNA hybridization in situ. The c-jun RNA concentration was significantly higher in condylomata specimens with E5a mRNA expression than in specimens without E5a mRNA expression, or in normal cervical specimens. The cells with c-jun expression were located predominantly in the basal and parabasal cell layers. These layers were also the primary location of E5a-expressing cells. This is the first demonstration of a strong correlation (74%) between expression of the E5a and c-jun genes in condylomata specimens. This correlation might reflect regulation by HPV-11 E5a of c-jun gene expression in condyloma.

^* Author for correspondence. Fax +886 2 3686028. e-mail slchen@ndmci.ndmctsgh.edu.tw

Received 28 November 1995; accepted 23 January 1996.

This article has been cited by other articles:

				J. Hu, R. Han, N. M. Cladel, M. D. Pickel, and N. D. Christensen Intracutaneous DNA Vaccination with the E8 Gene of Cottontail Rabbit Papillomavirus Induces Protective Immunity against Virus Challenge in Rabbits J. Virol., June 5, 2002; 76(13): 6453 - 6459. [Abstract] [Full Text] [PDF]